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Mechanism of action
Parasitic helminths must maintain an appropriate feeding site, and nematodes and trematodes must actively ingest and move food through their digestive tract to maintain an appropriate energy state, this requires proper neuromuscular co-ordination. The pharmacological basis of the treatment of helminthes generally involves interference with one or more of these functions that is destruction of energy process and subsequent starvation of the parasite or neuromuscular co-ordination leading to paralysis of the parasite and its subsequent expulsion. Benzimidazole acts in the same manner.
The drug is absorbed orally, approximately 47% of an oral dose was recovered (as metabolites) in the urine over a 9 day period. The active metabolites, albendazole sulphoxide and albendazole sulfone reached peak plasma concentrations 20 hours after dosing. Its anthelmintic activity is primarily due to the sulfoxide metabolite
Sheep & Goat 2 g. per 20 kg. b.wt.
Dog & Cat 2 g. per 10 kg. b.w.
Horse,Camel & pig 6 ml per 30 kg. b.wt.
Cattle 30 ml per100 kg. b.wt.
Sheep & Goat 6 ml per 30 kg. b.wt.
Dog and Cat 1 ml per 2.5 kg. b.wt
Horse,Camel & pig 5.0 mg per kg. b.w. or 1.5 g. bolus for 300 kg. b.wt.
Cattle 7.5 mg.per kg. b.wt. or 3.0 g. bolus for 400 kg.b.wt.
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