Veterinary Medicine

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• Albendazole is highly effective against round worms, lung worms, tape worms and liver flukes.
• It is effective against immature and mature worms.
• It is safe in young, old and debilitated animals and poultry.

Mechanism of action

Parasitic helminths must maintain an appropriate feeding site, and nematodes and trematodes must actively ingest and move food through their digestive tract to maintain an appropriate energy state, this requires proper neuromuscular co-ordination. The pharmacological basis of the treatment of helminthes generally involves interference with one or more of these functions that is destruction of energy process and subsequent starvation of the parasite or neuromuscular co-ordination leading to paralysis of the parasite and its subsequent expulsion. Benzimidazole acts in the same manner.

• Inhibition of enzyme in the glycolytic pathway.
• Inhibiting the breakdown of excitatory neurotransmitters by mimicking the action of the excitatory transmitter.

Pharmacokinetics

The drug is absorbed orally, approximately 47% of an oral dose was recovered (as metabolites) in the urine over a 9 day period. The active metabolites, albendazole sulphoxide and albendazole sulfone reached peak plasma concentrations 20 hours after dosing. Its anthelmintic activity is primarily due to the sulfoxide metabolite